Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 8/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | EBP | Q15125 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6593390 | 0.83 | OPRL1 (0.53) | OPRL1OPRM1OPRD1OPRK1ABCB11 | |
| SCHEMBL5151712 | 0.82 | OPRL1 (0.56) | OPRL1OPRM1OPRD1LMNAHTT | |
| SCHEMBL27458564 | 0.81 | HRH3 (0.49) | SMN1; SMN2KCNH2HRH3 | |
| SCHEMBL3454626 | 0.80 | OPRL1 (0.65) | OPRL1OPRM1OPRD1LMNAHTT | |
| SCHEMBL12642624 | 0.80 | OPRL1 (0.67) | OPRL1OPRM1OPRD1LMNAHTT | |
| SCHEMBL6190691 | 0.80 | OPRL1 (0.58) | OPRL1OPRM1OPRD1LMNAHTT | |
| SCHEMBL4587366 | 0.78 | DRD2 (0.56) | HTTCYP3A4CYP2D6TSHRMAPK1 | |
| SCHEMBL1887125 | 0.77 | LTA4H (0.61) | OPRL1OPRM1OPRD1LMNAHTT | |
| SCHEMBL6604382 | 0.75 | OPRL1 (0.46) | OPRL1OPRM1OPRD1OPRK1ABCB11 | |
| SCHEMBL6598869 | 0.74 | PPARG (0.47) | SIGMAR1KDM4EDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509351-B1 | A method of inhibiting TNF- alpha in a patient in need thereof which comprises administering to said patient an effective amount of a compound for inflamation | SANOFI-SYNTELABO (FR) | 2003-01-21 | — | — | US | disclosed |