Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27433120 | 0.80 | GRIN2B (0.58) | GRIN2BSLC6A4SLC6A3KDM4ECCR3 | |
| SCHEMBL27498930 | 0.78 | GRIN2B (0.59) | GRIN2B | |
| SCHEMBL27579148 | 0.78 | GRIN2B (0.41) | GRIN2BCCR3 | |
| SCHEMBL4672245 | 0.76 | GRIN2B (0.60) | GRIN2BSLC6A4SLC6A3 | |
| SCHEMBL4672241 | 0.76 | GRIN2B (0.60) | GRIN2BSLC6A4SLC6A3 | |
| SCHEMBL4672506 | 0.76 | GRIN2B (0.59) | GRIN2BCCR3 | |
| SCHEMBL4672504 | 0.76 | GRIN2B (0.59) | GRIN2BCCR3 | |
| SCHEMBL4672713 | 0.75 | GRIN2B (0.66) | GRIN2B | |
| SCHEMBL4672719 | 0.75 | GRIN2B (0.66) | GRIN2B | |
| SCHEMBL27608551 | 0.75 | GRIN1 (0.45) | GRIN2BKDM4ECCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1123571-C | 1-(3-heteroarylpropyl-or-prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists | MERCK PATENT GMBH (DE) | 2003-10-08 | — | — | CN | claimed |
| CN-1293673-A | 1- (3-heteroarylpropyl-or-prop-2-enyl) -4-benzylpiperidines as NMDA receptor antagonists | MERCK PATENT GMBH (DE) | 2001-05-02 | — | — | CN | claimed |
| CN-1123571-C | 1-(3-heteroarylpropyl-or-prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists | MERCK PATENT GMBH (DE) | 2003-10-08 | — | — | CN | disclosed |
| CN-1293673-A | 1- (3-heteroarylpropyl-or-prop-2-enyl) -4-benzylpiperidines as NMDA receptor antagonists | MERCK PATENT GMBH (DE) | 2001-05-02 | — | — | CN | disclosed |