Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.35 |
| ▸ | ARNT | P27540 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477654 | 0.70 | ALDH1A1 (0.49) | ALDH1A1POLBLMNAHPGDMAPT | |
| SCHEMBL8856476 | 0.68 | POLB (0.50) | MEN1KMT2AALDH1A1POLBLMNA | |
| SCHEMBL29222981 | 0.68 | SIRT6 (0.42) | MEN1KMT2AEPAS1ALDH1A1POLB | |
| SCHEMBL1995800 | 0.65 | TDP1 (0.46) | EPAS1ALDH1A1VEGFAABCC8KCNJ11 | |
| SCHEMBL11742334 | 0.65 | HASPIN (0.44) | MEN1KMT2AEPAS1ALDH1A1ABCC8 | |
| SCHEMBL7450322 | 0.64 | PDE7A (0.45) | MEN1KMT2AEPAS1ALDH1A1POLB | |
| SCHEMBL13542806 | 0.64 | ALDH1A1 (0.49) | EPAS1ARNTALDH1A1ABCC8KCNJ11 | |
| SCHEMBL102571 | 0.64 | EPAS1 (0.42) | MEN1KMT2AEPAS1ALDH1A1VEGFA | |
| SCHEMBL15966898 | 0.64 | TSHR (0.49) | EPAS1ALDH1A1VEGFAABCC8KCNJ11 | |
| SCHEMBL5316312 | 0.64 | EPAS1 (0.44) | EPAS1ARNTALDH1A1VEGFAABCC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158610-A | Quinoxaline derivatives useful in therapy | PFIZER LTD (IE) | 1997-09-03 | — | — | CN | disclosed |