SCHEMBL27462437

SCHEMBL27462437

COc1ccc2c(c1)C([Zr](Cl)(Cl)C1=CC=CC1)c1cc(OC)ccc1-2

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 2/20 0.34
HTR2A P28223 1/20 0.34
HTR2B P41595 1/20 0.34
MEN1 O00255 3/20 0.33
MAPT P10636 3/20 0.33
KMT2A Q03164 3/20 0.33
CYP3A4 P08684 3/20 0.33
CYP2C19 P33261 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C9 P11712 2/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
APP P05067 1/20 0.33
SNCA P37840 1/20 0.33
ACHE P22303 1/20 0.33
CYP1A1 P04798 1/20 0.33
CYP2E1 P05181 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9073081 0.79 GAA (0.35) HTR2AMEN1MAPTKMT2ACYP3A4
SCHEMBL27462918 0.76 GPR3 (0.32)
SCHEMBL4453488 0.72 GPR3 (0.30)
SCHEMBL27478548 0.69 MEN1 (0.33) HTR2CHTR2AHTR2BMEN1MAPT
SCHEMBL7886756 0.64 CA1 (0.41) MEN1MAPTKMT2ACYP3A4ALDH1A1
SCHEMBL5498591 0.64 CA1 (0.41) MAPTCYP3A4ALDH1A1RAB9ANPSR1
SCHEMBL868285 0.63 GPR3 (0.34) HTR2ACYP1A2CYP2D6
SCHEMBL5499565 0.63 ACHE (0.39) MAPTCYP3A4CYP2C19CYP1A2CYP2D6
SCHEMBL8896192 0.63 MEN1 (0.52) MEN1MAPTKMT2ACYP3A4CYP2C19
Hydrochloric Acid SCHEMBL7201110 0.61 CYP1A2 (0.46) HTR2CHTR2AHTR2BMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1160055-A Process for reducing by-product in product mixture HOECHST AG (DE) 1997-09-24 CN disclosed