Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10917587 | 1.00 | TSHR (0.50) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| SCHEMBL28001554 | 0.89 | TSHR (0.39) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Maleic Acid SCHEMBL3709578 | 0.86 | TSHR (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL3661879 | 0.86 | TSHR (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL3661882 | 0.86 | TSHR (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Bicarbonate SCHEMBL9005252 | 0.82 | CA1 (0.36) | HCAR2KMT2AMEN1LMNA | |
| Acrylic Acid SCHEMBL1191355 | 0.81 | LMNA (0.53) | TSHRALDH1A1LMNA | |
| Bicarbonate SCHEMBL29455645 | 0.79 | CA1 (0.33) | — | |
| Hydrogen Peroxide SCHEMBL27500303 | 0.78 | — | — | |
| Maleic Acid SCHEMBL27583410 | 0.78 | TSHR (0.82) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187928-B | A kind of preparation method of irsogladine maleate | 安徽省逸欣铭医药科技有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-106187928-A | A kind of preparation method of irsogladine maleate | 安徽省逸欣铭医药科技有限公司 | 2016-12-07 | — | — | CN | disclosed |
| CN-1270403-C | Circuit board device and its manufacturing mehtod | SONY CORP (JP) | 2006-08-16 | — | — | CN | disclosed |
| CN-1491448-A | Circuit board device and its manufacturing mehtod | ���ṫ˾ | 2004-04-21 | — | — | CN | disclosed |
| CN-1155244-A | Triazine derivative and medicine | NIPPON SHINYAKU CO LTD (JP) | 1997-07-23 | — | — | CN | disclosed |