Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.79 |
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.79 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24641954 | 0.93 | MAPT (0.83) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL3568725 | 0.89 | MAPT (0.64) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29855926 | 0.88 | MAPT (0.62) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8301729 | 0.86 | MGLL (0.64) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL6141536 | 0.85 | KMT2A (0.74) | MAPTALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL3048329 | 0.84 | MAPT (0.73) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL5539965 | 0.83 | MAPT (0.59) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL5539971 | 0.83 | MAPT (0.76) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29742046 | 0.83 | MAPT (0.58) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29742079 | 0.83 | MAPT (0.55) | MAPTALDH1A1LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |