Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.64 |
| ▸ | FAAH | O00519 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | BCL9 | O00512 | 1/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279984 | 0.90 | KMT2A (0.73) | MGLLFAAHKMT2AHRH2HRH1 | |
| SCHEMBL6141536 | 0.86 | KMT2A (0.74) | KMT2AHRH2HRH1SMN1; SMN2MEN1 | |
| SCHEMBL27464372 | 0.86 | MAPT (0.79) | KMT2AHRH2HRH1SMN1; SMN2MEN1 | |
| SCHEMBL7012374 | 0.82 | KMT2A (0.57) | MGLLFAAHKMT2AHRH2HRH1 | |
| SCHEMBL1734128 | 0.81 | MGLL (0.63) | MGLLFAAHALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3996605 | 0.81 | MGLL (0.63) | MGLLFAAHALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL4380521 | 0.80 | MGLL (0.65) | MGLLFAAHKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL1144551 | 0.80 | MGLL (0.62) | MGLLFAAHKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7009534 | 0.80 | KMT2A (0.60) | MGLLFAAHKMT2AHRH2HRH1 | |
| SCHEMBL3028258 | 0.80 | ALDH1A1 (0.49) | MGLLFAAHKMT2AHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |