Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301729 | 0.86 | MGLL (0.64) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL27464372 | 0.85 | MAPT (0.79) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL31495187 | 0.82 | GAA (0.59) | KMT2ASMN1; SMN2MEN1ALDH1A1KDM4E | |
| SCHEMBL9152022 | 0.80 | CA12 (0.77) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL3028258 | 0.79 | ALDH1A1 (0.49) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL29742079 | 0.78 | MAPT (0.55) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL3568725 | 0.78 | MAPT (0.64) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL2375175 | 0.78 | KMT2A (0.74) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL7838695 | 0.78 | PKM (0.64) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA | |
| SCHEMBL24641954 | 0.78 | MAPT (0.83) | KMT2ASMN1; SMN2MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551830-A2 | HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBATORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026829-A2 | HETEROCYCLICALLY SUBSTITUTED INDOLINONES AND THEIR USE AS RECEPTOR TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-04-01 | — | — | WO | disclosed |