SCHEMBL27464401

SCHEMBL27464401

CC(=C=O)C(N)(Oc1ccc(N2CCN(c3ccncc3)CC2)cc1)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.46
ITGA2B P08514 2/20 0.46
ALDH1A1 P00352 2/20 0.44
GAA P10253 1/20 0.44
HRH3 Q9Y5N1 5/20 0.42
PPARD Q03181 1/20 0.40
PPARA Q07869 1/20 0.40
CYP2C9 P11712 2/20 0.39
TSHR P16473 2/20 0.39
CYP2D6 P10635 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
KCNA5 P22460 1/20 0.38
SLC2A1 P11166 1/20 0.37
CCNC P24863 1/20 0.37
CDK8 P49336 1/20 0.37
HIF1A Q16665 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7403776 0.77 ITGB3 (0.53) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL8605223 0.73 ITGB3 (0.47) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL8633634 0.71 CYP2C9 (0.46) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL7330419 0.71 ITGB3 (0.50) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL8656238 0.71 ALDH1A1 (0.48) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL8635264 0.70 CYP2C9 (0.44) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL7810083 0.69 ALDH1A1 (0.69) ITGB3ITGA2BALDH1A1GAAPPARD
SCHEMBL8634899 0.68 TSHR (0.42) ITGB3ITGA2BALDH1A1GAAHRH3
SCHEMBL7406474 0.67 ITGB3 (0.47) ITGB3ITGA2BALDH1A1GAAHRH3
Butane SCHEMBL27464815 0.67 ITGB3 (0.47) ITGB3ITGA2BALDH1A1GAAHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1120334-A Heterocyclic derivatives as platelet aggregation inhibitors ZENECA LTD (GB) 1996-04-10 CN disclosed