Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28175224 | 0.78 | AOC3 (0.50) | AOC3NR4A2HRH4PSMB8 | |
| SCHEMBL4071480 | 0.77 | DAO (0.55) | DAOAOC3CYP1A2CYP2A6FLT3 | |
| SCHEMBL30939503 | 0.77 | DAO (0.55) | DAOAOC3CYP1A2CYP2A6FLT3 | |
| SCHEMBL28238792 | 0.75 | AOC3 (0.47) | AOC3NOS1FLT3HRH4PSMB8 | |
| SCHEMBL27277840 | 0.75 | DAO (0.62) | DAONOS1CYP1A2CYP2A6FLT3 | |
| SCHEMBL28251861 | 0.75 | DAO (0.53) | DAONOS1CYP1A2CYP2A6FLT3 | |
| SCHEMBL3632451 | 0.75 | DAO (0.53) | DAOAOC3FLT3HRH4GAA | |
| SCHEMBL27976842 | 0.75 | DAO (0.53) | DAONR4A2NOS1CYP1A2CYP2A6 | |
| SCHEMBL27792418 | 0.75 | IMPDH2 (0.47) | DAOAOC3HRH4 | |
| SCHEMBL4689767 | 0.75 | DAO (0.53) | DAONOS1CYP1A2CYP2A6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137100-C | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | ��ʲ | 2004-02-04 | — | — | CN | disclosed |
| CN-1139430-A | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family | WARNER LAMBERT CO (US) | 1997-01-01 | — | — | CN | disclosed |