SCHEMBL4689767

SCHEMBL4689767

Cc1cc2c(Cl)cccc2[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.53
CYP1A2 P05177 4/20 0.50
GAA P10253 3/20 0.50
RXFP1 Q9HBX9 2/20 0.50
HPGD P15428 1/20 0.46
HRH4 Q9H3N8 1/20 0.44
NOS1 P29475 1/20 0.42
CYP2A6 P11509 1/20 0.42
NQO2 P16083 1/20 0.42
FLT3 P36888 2/20 0.42
LMNA P02545 1/20 0.42
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ABCB11 O95342 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
PTGS1 P23219 1/20 0.38
SLC6A2 P23975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9584292 0.79 RHEB (0.47) CYP1A2GAARXFP1LMNAMAPT
SCHEMBL15829264 0.79 DAO (0.49) DAOCYP1A2GAAHRH4NOS1
SCHEMBL8230643 0.78 DAO (0.56) DAOCYP1A2GAARXFP1HPGD
SCHEMBL29713806 0.78 DAO (0.56) DAOCYP1A2GAARXFP1HPGD
SCHEMBL20940200 0.77 DAO (0.65) DAOCYP1A2HPGDHRH4LMNA
SCHEMBL5144384 0.77 DAO (0.41) DAOCYP1A2GAARXFP1HPGD
SCHEMBL7676067 0.75 HPGD (0.50) CYP1A2GAARXFP1HPGDHRH4
SCHEMBL933745 0.75 GAA (0.50) DAOCYP1A2GAARXFP1HRH4
SCHEMBL20461945 0.75 GAA (0.50) DAOCYP1A2GAARXFP1HPGD
SCHEMBL1353956 0.75 PARP1 (0.59) CYP1A2GAARXFP1HPGDHRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250263760-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-08-21 US disclosed
EP-4580621-A2 T-TYPE VOLTAGE-GATED CALCIUM CHANNEL POTENTIATORS The Broad Institute, Inc. (US) 2025-07-09 EP disclosed
US-12319946-B2 Methods for producing modified bacteria for production of nitroaromatics UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-06-03 US disclosed
EP-3928836-B1 N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2024-09-18 EP disclosed
US-20240229090-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-07-11 US disclosed
US-20240229090-A1 MODIFIED BACTERIA FOR PRODUCTION OF NITROAROMATICS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-07-11 US disclosed
US-12011444-B2 N-substituted indole derivatives as PGE2 receptor modulators IDORSIA PHARMACEUTICALS LTD (CH) 2024-06-18 US disclosed
WO-2024050312-A2 T-TYPE VOLTAGE-GATED CALCIUM CHANNEL POTENTIATORS THE BROAD INSTITUTE, INC. (US) 2024-03-07 WO disclosed
US-11879144-B2 Modified bacteria for production of nitroaromatics UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-01-23 US disclosed
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF ARBUTUS BIOPHARMA CORP (CA) 2023-10-05 US disclosed
US-20040224973-A1 Substituted indoles as alpha-1 agonists ROCHE PALO ALTO LLC 2004-11-11 US disclosed
WO-2004041776-A2 SULFONYLAMINOVALEROLAC TAMS AND DERIVATIVES THEREOF AS FACTOR Xa INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2004-05-21 WO disclosed
WO-2003087037-A1 SUBSTITUTED ARYL AMIDES MERCK & CO., INC. (US) 2003-10-23 WO disclosed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO disclosed
WO-2003077847-A2 SUBSTITUTED AMIDES MERCK & CO., INC. (US) 2003-09-25 WO disclosed
US-4465761-A HALO COMPOUND, LEUCO DYE, AROMATIC AMINE SENSITIZER, BINDER AND ALIPHATIC AMINE; ANTIFOGGING AGENTS ORIENTAL PHOTO INDUSTRIES CO., LTD. (JP) 1984-08-14 US disclosed
US-4416884-A ANTIBIOTIC, BACTERICIDE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1983-11-22 US disclosed
EP-0026859-B1 IMAGE-FORMING PHOTOSENSITIVE COMPOSITION, PHOTOSENSITIVE COATING SOLUTION AND PHOTOSENSITIVE SHEET COMPRISING THIS COMPOSITION ORIENTAL PHOTO INDUSTRIES, CO., LTD. (JP) 1983-10-05 EP disclosed
US-4317820-A β-Lactam series compound and antibacterial pharmaceutical composition containing the same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1982-03-02 US disclosed
EP-0026859-A2 Image-forming photosensitive composition, photosensitive coating solution and photosensitive sheet comprising this composition ORIENTAL PHOTO INDUSTRIES, CO., LTD. (JP) 1981-04-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040224973-A1 Substituted indoles as alpha-1 agonists ADRA1A, ADRB1, ADRA1D DAO 844/4885CYP1A2 346/4885GAA 3393/4885
US-12011444-B2 N-substituted indole derivatives as PGE2 receptor modulators PTGER1, PTGER4, PTGER2 DAO 3755/4885CYP1A2 104/4885GAA 4885/4885
US-20230312481-A1 SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF NSD3, PML, NSD1 DAO 878/4885CYP1A2 3133/4885GAA 2522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.