Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914288 | 0.92 | CDK2 (0.35) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7170682 | 0.77 | GLP1R (0.39) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7172045 | 0.73 | LMNA (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7859690 | 0.73 | KHK (0.45) | CCNE2CCNE1CDK2CCNA2LMNA | |
| SCHEMBL7168981 | 0.71 | KHK (0.36) | LMNA | |
| SCHEMBL7169151 | 0.67 | CDK2 (0.36) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7171751 | 0.67 | APP (0.38) | — | |
| SCHEMBL7859660 | 0.66 | GLP1R (0.41) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL7169449 | 0.66 | BCL6 (0.56) | TLR8CDK2SYKLMNAPOLB | |
| SCHEMBL1565794 | 0.65 | KHK (0.46) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136216-C | Pyrone carboxylic acid derivate or its salt and antibiotic with the same as effective component | ������ҩ��ʽ���� | 2004-01-28 | — | — | CN | disclosed |