Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betanaphthol SCHEMBL27450332 | 0.85 | CYP1A2 (0.44) | KIF11CYP1A2BCL2L1BADALDH1A1 | |
| Quinoline SCHEMBL27663487 | 0.84 | ALDH1A1 (0.43) | KIF11CYP1A2TSHRALDH1A1KDM4E | |
| Isoquinoline SCHEMBL28753569 | 0.84 | NCOA3 (0.35) | KIF11CYP1A2TSHRALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL28811976 | 0.84 | NCOA3 (0.35) | KIF11CYP1A2TSHRALDH1A1KDM4E | |
| SCHEMBL27431341 | 0.84 | CYP1A2 (0.48) | KIF11CYP1A2CYP2A6BCL2L1BAD | |
| SCHEMBL27288088 | 0.80 | KIF11 (0.47) | KIF11CYP1A2TSHRCYP2A6BCL2L1 | |
| SCHEMBL28125993 | 0.79 | KIF11 (0.41) | KIF11CDK4CCND1ALDH1A1KDM4E | |
| SCHEMBL30662035 | 0.79 | BCL2L1 (0.48) | KIF11TSHRBCL2L1BADCDK4 | |
| SCHEMBL27528878 | 0.79 | BCL2L1 (0.48) | KIF11TSHRBCL2L1BADCDK4 | |
| SCHEMBL27632129 | 0.79 | KIF11 (0.46) | KIF11TSHRBCL2L1BADCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1131230-C | Tricyclic delta 3-piperidines as alpha 2-antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2003-12-17 | — | — | CN | disclosed |
| CN-1332744-A | As α2Tricyclic delta 3-piperidines as antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-23 | — | — | CN | disclosed |