Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | KHK | P50053 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23763865 | 1.00 | HTR3A (0.59) | HTR3AKHKJAK3 | |
| SCHEMBL17297898 | 0.91 | HTR3A (0.49) | HTR3A | |
| Enefexine SCHEMBL499360 | 0.89 | SLC18A3 (0.55) | HTR3A | |
| Enefexine SCHEMBL4886231 | 0.87 | SLC18A3 (0.53) | HTR3A | |
| SCHEMBL17825381 | 0.86 | HTR3A (0.56) | HTR3AJAK3 | |
| SCHEMBL10265352 | 0.84 | ALDH1A1 (0.42) | HTR3A | |
| SCHEMBL17825531 | 0.83 | HTR3A (0.53) | HTR3A | |
| Hydrochloric Acid SCHEMBL14861746 | 0.82 | ALDH1A1 (0.41) | HTR3A | |
| SCHEMBL28258195 | 0.81 | HTR3A (0.59) | HTR3AJAK3 | |
| SCHEMBL28004262 | 0.81 | HTR3A (0.59) | HTR3AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1150165-C | 1-arylsulfonyl-2-aryl-pyrrolidine derivatives for the treatment of central nervous system disorders | - | 2004-05-19 | — | — | CN | disclosed |
| CN-1345311-A | 1-arenesulfonyl-2-aryl-pyrolidine and piperidine derivatives for treatment of CNS disorders | HOFFMANN LA ROCHE (CH) | 2002-04-17 | — | — | CN | disclosed |