Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.60 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12273379 | 0.83 | DHODH (0.69) | KDM4ELMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4852085 | 0.79 | HTT (0.73) | KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8440112 | 0.79 | ALOX15 (0.53) | KDM4ESMN1; SMN2CYP3A4KMT2AMEN1 | |
| SCHEMBL1062154 | 0.79 | PDE10A (0.55) | ABCB1ABCC1ABCG2KDM4EPDE10A | |
| SCHEMBL379807 | 0.78 | LMNA (0.76) | KDM4EPDE10ALMNASMN1; SMN2CYP3A4 | |
| SCHEMBL29586433 | 0.78 | LMNA (0.76) | KDM4EPDE10ALMNASMN1; SMN2CYP3A4 | |
| SCHEMBL8617753 | 0.77 | ACP1 (0.51) | ABCB1ABCC1ABCG2KDM4EPDE10A | |
| SCHEMBL15919345 | 0.77 | ACP1 (0.51) | ABCB1ABCC1ABCG2KDM4EPDE10A | |
| SCHEMBL28193696 | 0.76 | SLC2A1 (0.56) | ABCB1ABCC1ABCG2KDM4EPDE10A | |
| SCHEMBL10508186 | 0.75 | KDM4E (0.58) | KDM4EPDE10ALMNASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178091-B2 | Compositions and methods for the treatment of respiratory disorders | UNIVERSITY OF WASHINGTON (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090016967-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS | UNIVERSITY OF WASHINGTON (US) | 2009-01-15 | — | — | US | disclosed |
| WO-2008144720-A2 | INHIBITORS OF IGF-1R SIGNALING FOR THE TREATMENT OF RESPIRATORY DISORDERS | UNIVERSITY OF WASHINGTON (US) | 2008-11-27 | — | — | WO | disclosed |