Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012498 | 0.80 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL8327321 | 0.76 | PLA2G1B (0.43) | HTR1ASLC6A2SLC6A4SLC6A3NPC1 | |
| SCHEMBL9080973 | 0.74 | KMT2A (0.41) | HTR1ASLC6A2SLC6A4SLC6A3NPC1 | |
| SCHEMBL7011291 | 0.70 | HTR1A (0.43) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL13805728 | 0.69 | MAPT (0.45) | HTR1ACCNB2CDK1CDK4CCNB1 | |
| SCHEMBL12836290 | 0.69 | HTR1A (0.79) | HTR1ASLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL1572818 | 0.69 | MAPK1 (0.46) | HTR1AMAPTL3MBTL1MAPK14MEN1 | |
| SCHEMBL8322428 | 0.68 | PLA2G1B (0.51) | HTR1ACCNB2CDK1CDK4CCNB1 | |
| SCHEMBL183812 | 0.67 | CCNB2 (0.57) | HTR1ACCNB2CDK1CDK4CCNB1 | |
| SCHEMBL7013077 | 0.66 | MAPT (0.52) | HTR1ASLC6A2SLC6A4SLC6A3CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |