Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482760 | 0.90 | HPGD (0.33) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 | |
| SCHEMBL27466731 | 0.87 | HDAC8 (0.40) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 | |
| SCHEMBL27504947 | 0.87 | HDAC8 (0.38) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 | |
| SCHEMBL27466734 | 0.80 | HDAC8 (0.38) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 | |
| SCHEMBL27466722 | 0.79 | HDAC8 (0.48) | HDAC8HDAC6HDAC1 | |
| SCHEMBL27552955 | 0.78 | SLC6A4 (0.30) | SLC6A4SLC6A3 | |
| SCHEMBL27482758 | 0.78 | MDM2 (0.41) | HDAC8HDAC6HDAC1SLC6A3 | |
| SCHEMBL27466725 | 0.77 | KMT2A (0.45) | HDAC8HDAC6HDAC1 | |
| SCHEMBL27480883 | 0.74 | HDAC8 (0.51) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 | |
| SCHEMBL27511646 | 0.74 | SLC6A4 (0.35) | HDAC8HDAC6HDAC1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151140-C | Glucokinase activators | - | 2004-05-26 | — | — | CN | disclosed |
| CN-1349519-A | Glucokinase activators | HOFFMANN LA ROCHE (CH) | 2002-05-15 | — | — | CN | disclosed |