Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.49 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.49 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27503386 | 1.00 | GRIK1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL27484664 | 1.00 | GRIK1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29378321 | 0.87 | LDHA (0.60) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29965330 | 0.87 | LDHA (0.60) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29339 | 0.86 | LDHA (0.55) | LDHAALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL5973191 | 0.86 | LDHA (0.55) | LDHAALDH1A1KMT2AMEN1HSD17B10 | |
| SCHEMBL598291 | 0.86 | LDHA (0.55) | LDHAALDH1A1KMT2AMEN1HSD17B10 | |
| Hydrochloric Acid SCHEMBL5973458 | 0.84 | LDHA (0.54) | LDHASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL5973459 | 0.84 | LDHA (0.54) | LDHASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL25183050 | 0.83 | GRIA2 (0.40) | GRIK1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167580-A | Pharmaceutical composition and method for treating cancer | 迪美公司 | 2019-08-23 | — | — | CN | claimed |
| CN-110062633-A | Tyrosine derivatives and compositions comprising the same | 迪美公司 | 2019-07-26 | — | — | CN | claimed |
| CN-109562116-A | Protona and protona derivative and promotor in cancer treatment | 迪美公司 | 2019-04-02 | — | — | CN | claimed |
| CN-109195601-A | Pharmaceutical composition for treating cancer | 迪美公司 | 2019-01-11 | — | — | CN | claimed |
| CN-106232105-A | Tyrosine derivative and comprise the compositions of tyrosine derivative | 迪美公司 | 2016-12-14 | — | — | CN | claimed |
| CN-105848771-A | High-speed centrifugal mixing devices and methods of use | 迪美公司 | 2016-08-10 | — | — | CN | claimed |
| CN-105848652-A | Tyrosine hydroxylase inhibitors for the treatment of intestinal hyperpermeability | 史蒂文·霍夫曼 | 2016-08-10 | — | — | CN | claimed |
| CN-104220057-A | Pharmaceutical compositions and methods | TYME INC | 2014-12-17 | — | — | CN | claimed |
| CN-115515575-A | Tyrosine derivatives for the modulation of cancer | 迪美公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-110167580-A | Pharmaceutical composition and method for treating cancer | 迪美公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-109195601-A | Pharmaceutical composition for treating cancer | 迪美公司 | 2019-01-11 | — | — | CN | disclosed |
| CN-106232105-A | Tyrosine derivative and comprise the compositions of tyrosine derivative | 迪美公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-104220057-A | Pharmaceutical compositions and methods | TYME INC | 2014-12-17 | — | — | CN | disclosed |
| CN-1165337-C | Synthetic cryptophycins | ���Ĵ���ѧ | 2004-09-08 | — | — | CN | disclosed |
| CN-1183726-A | Synthetic cryptophycins | UNIV HAWAII (US) | 1998-06-03 | — | — | CN | disclosed |