Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nomegestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 6/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.66 |
| ▸ | AR | P10275 | 4/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SHBG | P04278 | 2/20 | 0.47 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nomegestrol SCHEMBL37518 | 0.97 | LMNA (0.77) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol SCHEMBL19760878 | 0.95 | LMNA (0.80) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol SCHEMBL139763 | 0.95 | LMNA (0.80) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol SCHEMBL6415665 | 0.94 | LMNA (0.79) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol SCHEMBL4913845 | 0.93 | LMNA (0.74) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| SCHEMBL9322389 | 0.88 | LMNA (0.82) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Acetic Acid SCHEMBL282894 | 0.86 | CYP2C19 (0.62) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| SCHEMBL141181 | 0.84 | CYP2C19 (0.64) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol Acetate SCHEMBL37517 | 0.80 | PGR (1.00) | LMNACYP3A4CYP2C19CYP2C9PGR | |
| Nomegestrol Acetate SCHEMBL8817628 | 0.80 | PGR (1.00) | LMNACYP3A4CYP2C19CYP2C9PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1161102-C | Systemic topical hormone compositions | ̩��÷˹ʵ���� | 2004-08-11 | — | — | CN | disclosed |
| CN-1407898-A | Novel topical oestroprogestational compositions with systemic effect | THERAMEX (MC) | 2003-04-02 | — | — | CN | disclosed |
| CN-1301146-A | Topical hormonal composition with systemic effect | THERAMEX (MC) | 2001-06-27 | — | — | CN | disclosed |