Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nomegestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR known ✓ | P06401 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 5/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.79 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.71 |
| ▸ | AR | P10275 | 4/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SHBG | P04278 | 1/20 | 0.50 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nomegestrol SCHEMBL19760878 | 0.99 | LMNA (0.80) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol SCHEMBL139763 | 0.99 | LMNA (0.80) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol SCHEMBL37518 | 0.97 | LMNA (0.77) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol SCHEMBL27486762 | 0.94 | LMNA (0.76) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol SCHEMBL4913845 | 0.92 | LMNA (0.74) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| SCHEMBL9322389 | 0.88 | LMNA (0.82) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| SCHEMBL141181 | 0.88 | CYP2C19 (0.64) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Acetic Acid SCHEMBL282894 | 0.86 | CYP2C19 (0.62) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol Acetate SCHEMBL37517 | 0.83 | PGR (1.00) | LMNACYP3A4CYP2C9CYP2C19PGR | |
| Nomegestrol Acetate SCHEMBL8817628 | 0.83 | PGR (1.00) | LMNACYP3A4CYP2C9CYP2C19PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005123046-A1 | NOVEL TRANSDERMAL PREPARATION AND ITS PRODUCING METHOD | AMOREPACIFIC CORPORATION (KR) | 2005-12-29 | — | — | WO | claimed |
| CN-112871079-A | Preparation method and preparation device of nomegestrol acetate particles | 丽江映华生物药业有限公司 | 2021-06-01 | — | — | CN | disclosed |
| WO-2005123046-A1 | NOVEL TRANSDERMAL PREPARATION AND ITS PRODUCING METHOD | AMOREPACIFIC CORPORATION (KR) | 2005-12-29 | — | — | WO | disclosed |