Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27470573 | 0.85 | MAPK14 (0.40) | MAPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27488607 | 0.80 | PTGS1 (0.41) | MAPTMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27488957 | 0.76 | SMN1; SMN2 (0.40) | MAPK14LMNAALDH1A1HPGDRXFP1 | |
| SCHEMBL27522828 | 0.75 | FYN (0.39) | MAPK14AKT2 | |
| SCHEMBL27488242 | 0.74 | PTGS2 (0.49) | MAPTLMNAALDH1A1HPGDKDM4E | |
| SCHEMBL27471546 | 0.72 | SMN1; SMN2 (0.45) | MAPTMAPK14LMNAALDH1A1HPGD | |
| SCHEMBL27470080 | 0.72 | MAPT (0.38) | MAPTMAPK14LMNAALDH1A1MEN1 | |
| SCHEMBL27587261 | 0.70 | PTGS2 (0.47) | MAPTMAPK14LMNAALDH1A1HPGD | |
| SCHEMBL14198825 | 0.69 | IDO1 (0.46) | LMNAKMT2A | |
| SCHEMBL15577532 | 0.68 | PIK3CA (0.55) | MAPK14MAPK13MAPK12MAPK11RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167687-C | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ���Ͽع�����˾ | 2004-09-22 | — | — | CN | disclosed |
| CN-1277605-A | Arylpyridazinones as prostaglandin endoperoxide H synthase biosynthesis inhibitors | ABBOTT LAB (US) | 2000-12-20 | — | — | CN | disclosed |