Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27942916 | 0.79 | SMN1; SMN2 (0.42) | LMNACYP1A2SLC6A2 | |
| SCHEMBL1728265 | 0.77 | CA12 (0.46) | MRGPRX4EGFRHTR2AMAPK10MAPK14 | |
| SCHEMBL28500626 | 0.76 | MRGPRX4 (0.42) | MRGPRX4GCKEGFRHTR1ALMNA | |
| SCHEMBL2883927 | 0.72 | L3MBTL1 (0.51) | MRGPRX4CFDEGFRLMNACYP1A2 | |
| SCHEMBL27562901 | 0.72 | SLC6A4 (0.44) | HTR2ASLC6A2 | |
| SCHEMBL27477682 | 0.72 | HTR1A (0.40) | HTR1APDE7ASLC6A2 | |
| SCHEMBL20800776 | 0.72 | ALDH1A1 (0.36) | — | |
| SCHEMBL521826 | 0.71 | MRGPRX4 (0.40) | MRGPRX4CFDGCKIDO1KAT2B | |
| SCHEMBL27896749 | 0.70 | L3MBTL1 (0.42) | HTR1ALMNACYP1A2SLC6A2 | |
| SCHEMBL320817 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1210279-C | Novel thiazolo (4, 5-D) pyrimidine compounds | ASTRAZENECA UK LTD (GB) | 2005-07-13 | — | — | CN | disclosed |
| CN-1402730-A | Thiazolo (4,5-D) pyrimidine compounds | ASTRAZENECA UK LTD (GB) | 2003-03-12 | — | — | CN | disclosed |