Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775974 | 0.77 | NR1H2 (0.33) | — | |
| SCHEMBL19919573 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2CRBN | |
| SCHEMBL31694894 | 0.75 | KDM4E (0.34) | — | |
| SCHEMBL6176253 | 0.69 | KDM4E (0.30) | — | |
| SCHEMBL27047057 | 0.68 | CRBN (0.38) | SMN1; SMN2CRBN | |
| SCHEMBL22445809 | 0.68 | SMN1; SMN2 (0.35) | SMN1; SMN2CRBN | |
| SCHEMBL16825004 | 0.65 | SOS1 (0.42) | — | |
| SCHEMBL21847510 | 0.65 | — | — | |
| SCHEMBL18185800 | 0.64 | SMN1; SMN2 (0.48) | SMN1; SMN2 | |
| SCHEMBL19280067 | 0.64 | SMN1; SMN2 (0.35) | SMN1; SMN2CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1207289-C | Metalloprotease inhibitors, pharmaceutical compositions containing them and their use as medicaments, process and intermediates for their preparation | AGOURON PHARMA (US) | 2005-06-22 | — | — | CN | disclosed |
| CN-1542002-A | Inhibitors of metalloproteinase, pharmaceutical compositions containing them, their pharmaceutical application and methods and intermediate compounds for their preparation | ������ҩ������˾ | 2004-11-03 | — | — | CN | disclosed |
| CN-1207734-A | Metalloprotease inhibitors, pharmaceutical compositions containing them and their use as medicaments, process and intermediates for their preparation | AGOURON PHARMA (US) | 1999-02-10 | — | — | CN | disclosed |