Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 7/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230440 | 0.84 | PDE4D (0.60) | PDE4DKDM4EMAPTL3MBTL1PDE4A | |
| SCHEMBL27504690 | 0.79 | MAP4K4 (0.44) | KDM4EL3MBTL1POLBTDP1ALDH1A1 | |
| SCHEMBL7232506 | 0.78 | PDE4D (0.53) | PDE4DKDM4EMAPTNPSR1L3MBTL1 | |
| SCHEMBL4049358 | 0.78 | DYRK1A (0.51) | PDE4DKDM4EMAPTL3MBTL1PDE4A | |
| SCHEMBL9002865 | 0.78 | PDE4D (0.61) | PDE4DKDM4EMAPTNPSR1L3MBTL1 | |
| SCHEMBL6433855 | 0.78 | PDE4D (0.55) | PDE4DKDM4EMAPTNPSR1L3MBTL1 | |
| SCHEMBL7230945 | 0.77 | PDE4D (0.64) | PDE4DKDM4EMAPTNPSR1L3MBTL1 | |
| SCHEMBL7273341 | 0.76 | PDE4D (0.60) | PDE4DKDM4EMAPTPDE4APDE4C | |
| SCHEMBL10768030 | 0.76 | PDE4D (0.60) | PDE4DKDM4EMAPTPDE4APDE4C | |
| SCHEMBL6717844 | 0.76 | ALDH1A1 (0.48) | KDM4EMAPTL3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1214008-C | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2005-08-10 | — | — | CN | disclosed |
| CN-1312800-A | Therapeutic biaryl derivatives | GLAXO GROUP LTD (GB) | 2001-09-12 | — | — | CN | disclosed |