Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetone SCHEMBL4780811 | 1.00 | LMNA (0.42) | LMNAALDH1A1TRPA1THRBOR51E2 | |
| SCHEMBL2945693 | 0.85 | — | — | |
| SCHEMBL370747 | 0.85 | — | — | |
| SCHEMBL2949083 | 0.85 | — | — | |
| Glycerin SCHEMBL1831824 | 0.82 | LMNA (0.64) | LMNAALDH1A1THRBOR51E2TDP1 | |
| Glycerin SCHEMBL93722 | 0.82 | LMNA (0.64) | LMNAALDH1A1THRBOR51E2TDP1 | |
| Glycerin SCHEMBL4554867 | 0.82 | LMNA (0.64) | LMNAALDH1A1THRBOR51E2TDP1 | |
| Trimethylammonium SCHEMBL15820997 | 0.80 | ALDH1A1 (0.44) | LMNAALDH1A1THRBTDP1TSHR | |
| Glycerin SCHEMBL10878473 | 0.79 | LMNA (0.60) | LMNAALDH1A1THRBOR51E2TDP1 | |
| Acetone SCHEMBL9777640 | 0.79 | THRB (0.43) | LMNAALDH1A1TRPA1THRBOR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178539-B2 | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2012-05-15 | — | — | US | disclosed |
| US-20100173906-A1 | Substituted 3,4,6,7-Tetrahydro-5H-1,2a,4a,8-Tetraazacyclopenta[cd]Phenalenes and Methods | 3M INNOVATIVE PROPERTIES COMPANY | 2010-07-08 | — | — | US | disclosed |
| WO-2008030511-A2 | SUBSTITUTED 3,4,6,7-TETRAHYDRO-5H, 1,2A,4A,8-TETRAAZACYCLOPENTA[CD]PHENALENES | COLEY PHARMACEUTICIAL GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173906-A1 | Substituted 3,4,6,7-Tetrahydro-5H-1,2a,4a,8-Tetraazacyclopenta[cd]Phenalenes and Methods | IL2, IL15, IL17A | LMNA 3119/4885ALDH1A1 530/4885TRPA1 3650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.