Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 17/20 | 0.57 |
| ▸ | NPC1 | O15118 | 15/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.57 |
| ▸ | TP53 | P04637 | 6/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.57 |
| ▸ | RELA | Q04206 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27535427 | 0.82 | EDNRA (0.66) | EDNRBEDNRASMN1; SMN2HPGDMEN1 | |
| SCHEMBL6151248 | 0.78 | EDNRA (0.81) | EDNRBEDNRA | |
| SCHEMBL27497626 | 0.77 | KMT2A (0.57) | EDNRBEDNRARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27496628 | 0.76 | EDNRA (0.58) | EDNRBEDNRARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6151116 | 0.76 | EDNRA (1.00) | EDNRBEDNRA | |
| SCHEMBL7532022 | 0.73 | HPGD (0.57) | EDNRBEDNRARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27496308 | 0.73 | TAS1R3 (0.47) | EDNRBEDNRASMN1; SMN2HPGDMEN1 | |
| SCHEMBL471080 | 0.72 | MAPT (0.57) | EDNRBEDNRAHPGDPKMMEN1 | |
| SCHEMBL14701156 | 0.72 | EDNRB (0.54) | EDNRBEDNRAHPGDPKMMEN1 | |
| SCHEMBL12293031 | 0.72 | EDNRB (0.54) | EDNRBEDNRAHPGDPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1216045-A | N- (2,1, 3-benzothia (oxa) diazolyl) sulfonamides having endothelin receptor antagonistic effect | MERCK PATENT GMBH (DE) | 1999-05-05 | — | — | CN | disclosed |