Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27498855 | 0.86 | MEN1 (0.34) | MAPTNPSR1HTTALDH1A1TBXA2R | |
| SCHEMBL27500364 | 0.85 | ALDH1A1 (0.37) | LMNAMAPTNPSR1ALDH1A1TBXA2R | |
| SCHEMBL27535554 | 0.85 | NPC1 (0.43) | LMNAMAPTNPSR1GPR55POLB | |
| SCHEMBL27566023 | 0.84 | POLB (0.40) | LMNAMAPTNPSR1GPR55POLB | |
| SCHEMBL27539107 | 0.82 | LMNA (0.41) | LMNAMAPTNPSR1GPR55POLB | |
| SCHEMBL27539426 | 0.82 | HCAR3 (0.37) | LMNAMAPTNPSR1HTTALDH1A1 | |
| SCHEMBL27484338 | 0.82 | ALDH1A1 (0.35) | NPSR1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL27539464 | 0.80 | ALDH1A1 (0.41) | LMNAMAPTNPSR1GPR55CYP1A2 | |
| SCHEMBL27485133 | 0.78 | TBXA2R (0.45) | MAPTNPSR1POLBCYP3A4HTT | |
| SCHEMBL27472206 | 0.78 | LMNA (0.49) | LMNAMAPTNPSR1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264825-C | Dihydro-benzo [ b ] [1,4] diazepin * -2-one derivatives as mGluR2 antagonists II | HOFFMANN LA ROCHE (CH) | 2006-07-19 | — | — | CN | disclosed |
| CN-1195522-C | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2005-04-06 | — | — | CN | disclosed |
| CN-1535266-A | Dihydro-benzo [b][1,4] diazepin-2-one derivatives as mglur 2 antagonists II | - | 2004-10-06 | — | — | CN | disclosed |
| CN-1379765-A | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |