Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414554 | 0.79 | NPC1 (0.57) | SMN1; SMN2RAB9AKDM4ENPC1HPGD | |
| SCHEMBL2710881 | 0.75 | RAB9A (0.51) | SMN1; SMN2RAB9ARXFP1KDM4ENPC1 | |
| SCHEMBL27517650 | 0.75 | KMO (0.54) | SMN1; SMN2RAB9APOLBRXFP1KDM4E | |
| SCHEMBL27516586 | 0.75 | RAB9A (0.58) | SMN1; SMN2RAB9APOLBRXFP1NPC1 | |
| SCHEMBL12171339 | 0.71 | NPC1 (0.71) | SMN1; SMN2RAB9AKDM4ENPC1HPGD | |
| SCHEMBL5640575 | 0.71 | RAB9A (0.71) | SMN1; SMN2RAB9ARXFP1NPC1HPGD | |
| SCHEMBL8840154 | 0.70 | NPC1 (0.65) | SMN1; SMN2RAB9AKDM4ENPC1HPGD | |
| SCHEMBL11610592 | 0.70 | NPC1 (0.70) | SMN1; SMN2RAB9AKDM4ENPC1HPGD | |
| SCHEMBL12171377 | 0.70 | CA1 (0.53) | SMN1; SMN2RAB9AKDM4ENPC1HPGD | |
| SCHEMBL30566761 | 0.70 | SMN1; SMN2 (0.69) | SMN1; SMN2RAB9APOLBKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1740169-B | Arylmethylamine derivatives for use as tryptase inhibitors | AVENTIS PHARMA INC | 2010-04-21 | — | — | CN | disclosed |
| CN-1740169-A | Arylmethylamine derivatives for use as tryptase inhibitors | AVENTIS PHARMA INC (US) | 2006-03-01 | — | — | CN | disclosed |
| CN-1230431-C | Arylmethylamine derivatives useful as tryptase inhibitors | AVENTIS PHARM PROD INC (US) | 2005-12-07 | — | — | CN | disclosed |
| CN-1439003-A | Arylmethylamine derivatives useful as tryptase inhibitors | AVENTIS PHARM PROD INC (US) | 2003-08-27 | — | — | CN | disclosed |