Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334419 | 0.77 | CYP4F2 (0.64) | FOLH1KMT2ATDP1CYP4F2CYP4A11 | |
| Hydrochloric Acid SCHEMBL11527299 | 0.75 | CYP4F2 (0.62) | FOLH1KMT2ATDP1CYP4F2CYP4A11 | |
| SCHEMBL27515542 | 0.75 | FOLH1 (0.46) | RAB9ASMN1; SMN2RXFP1NPC1FOLH1 | |
| SCHEMBL30791058 | 0.75 | FOLH1 (0.70) | FOLH1KMT2ACA1CA2CA9 | |
| SCHEMBL70351 | 0.75 | FOLH1 (0.70) | FOLH1KMT2ACA1CA2CA9 | |
| SCHEMBL27500508 | 0.75 | SMN1; SMN2 (0.55) | RAB9ASMN1; SMN2RXFP1NPC1L3MBTL1 | |
| SCHEMBL2438255 | 0.74 | HPGD (0.72) | RAB9ASMN1; SMN2RXFP1NPC1L3MBTL1 | |
| SCHEMBL2710881 | 0.74 | RAB9A (0.51) | RAB9ASMN1; SMN2RXFP1NPC1L3MBTL1 | |
| SCHEMBL27517650 | 0.74 | KMO (0.54) | RAB9ASMN1; SMN2RXFP1NPC1L3MBTL1 | |
| SCHEMBL1926951 | 0.71 | FOLH1 (0.66) | FOLH1KMT2ACA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264825-C | Dihydro-benzo [ b ] [1,4] diazepin * -2-one derivatives as mGluR2 antagonists II | HOFFMANN LA ROCHE (CH) | 2006-07-19 | — | — | CN | disclosed |
| CN-1535266-A | Dihydro-benzo [b][1,4] diazepin-2-one derivatives as mglur 2 antagonists II | - | 2004-10-06 | — | — | CN | disclosed |