Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597321 | 0.94 | NPC1 (0.43) | NPC1RAB9AALDH1A1PKML3MBTL1 | |
| SCHEMBL4690356 | 0.76 | PDGFRB (0.53) | PDGFRBFGFR1KDRCHEK1JAK1 | |
| SCHEMBL27520970 | 0.73 | CHEK1 (0.50) | NPC1RAB9AALDH1A1PKMKDM4E | |
| SCHEMBL4285737 | 0.69 | CHEK1 (0.61) | CDK2ADORA3PDGFRBFGFR1KDR | |
| SCHEMBL17566737 | 0.69 | WNT1 (0.64) | CDK2WNT1TGFBR1PDPK1FGFR1 | |
| SCHEMBL10264582 | 0.68 | ATR (0.62) | ALDH1A1HPGDSMN1; SMN2NPSR1ATR | |
| SCHEMBL4285975 | 0.67 | CHEK1 (0.64) | NPC1RAB9AALDH1A1KDM4ECDK2 | |
| SCHEMBL4286313 | 0.67 | CHEK1 (0.64) | NPC1RAB9AALDH1A1KDM4EHPGD | |
| SCHEMBL4291461 | 0.66 | CHEK1 (0.62) | CDK2CHEK1JAK1 | |
| SCHEMBL3379867 | 0.65 | CHEK1 (0.75) | CDK2PDGFRBFGFR1KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100526312-C | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2009-08-12 | — | — | CN | disclosed |
| CN-1692112-A | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2005-11-02 | — | — | CN | disclosed |
| CN-1659165-A | Quinolinone derivatives | CHIRON CORP (US) | 2005-08-24 | — | — | CN | disclosed |
| CN-1483028-A | Quinolinone derivatives as tyrosine kinase inhibitors | ϣ | 2004-03-17 | — | — | CN | disclosed |
| CN-1226283-A | Recombinant enzyme with dextranase activity | NOVO NORDISK AS (DK) | 1999-08-18 | — | — | CN | disclosed |