Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 15/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379867 | 0.83 | CHEK1 (0.75) | PDGFRBFGFR1KDRCHEK1JAK1 | |
| SCHEMBL3378308 | 0.79 | CHEK1 (0.75) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL14795486 | 0.76 | CHEK1 (0.76) | CHEK1JAK1 | |
| SCHEMBL27503545 | 0.76 | NPC1 (0.45) | PDGFRBFGFR1KDRCHEK1JAK1 | |
| SCHEMBL14795468 | 0.73 | PDGFRB (0.58) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL3379145 | 0.71 | CHEK1 (0.81) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL3384480 | 0.71 | CHEK1 (0.81) | PDGFRBFGFR1KDRCHEK1 | |
| SCHEMBL14796613 | 0.70 | FGFR1 (0.51) | PDGFRBFGFR1KDRCHEK1FLT1 | |
| SCHEMBL27597321 | 0.70 | NPC1 (0.43) | CHEK1 | |
| SCHEMBL14796041 | 0.70 | CHEK1 (0.86) | PDGFRBFGFR1KDRCHEK1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1650203-B1 | Process of preparation of benzimidazol-2-yl quinolinone derivatives | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2008-02-20 | — | — | EP | disclosed |