Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27505260 | 0.90 | MAPK8 (0.38) | ADRA1DMAPK8KLKB1KLK1JAK2 | |
| SCHEMBL27530677 | 0.87 | PLA2G10 (0.42) | ADRA1DKLKB1KLK1BRD4 | |
| SCHEMBL27530259 | 0.87 | IDO1 (0.40) | MAPK8FEN1LMNAPOLB | |
| SCHEMBL7754856 | 0.86 | ADRA1D (0.47) | ADRA1DCCR2MAPK8KLKB1KLK1 | |
| SCHEMBL27530159 | 0.86 | PARP15 (0.41) | MAPK8FEN1SIRT2SIRT1LMNA | |
| SCHEMBL27563188 | 0.85 | PLA2G2A (0.41) | ADRA1D | |
| SCHEMBL27525956 | 0.85 | PLA2G1B (0.47) | ADRA1DCCR2MAPK8LMNA | |
| SCHEMBL27506885 | 0.85 | ADRA1D (0.41) | ADRA1DMAPK8KLKB1BRD4POLB | |
| SCHEMBL27505567 | 0.85 | PLA2G2A (0.37) | BRD4LMNA | |
| SCHEMBL27525731 | 0.85 | MAPK8 (0.38) | MAPK8KLKB1FAAHBRD4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1240210-A | Substituted tricyclic compound | LILLY CO ELI (US) | 2000-01-05 | — | — | CN | disclosed |