Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693185 | 0.85 | KMT2A (0.77) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL6439308 | 0.84 | KMT2A (1.00) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL4687342 | 0.83 | KMT2A (0.73) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL21504906 | 0.83 | KMT2A (0.73) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL2751737 | 0.81 | KMT2A (0.76) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL18658002 | 0.81 | CCR3 (0.78) | KMT2ASMN1; SMN2MEN1HTTKDM4E | |
| SCHEMBL2751300 | 0.80 | ALDH1A1 (0.70) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL813710 | 0.80 | KMT2A (0.79) | KMT2ASMN1; SMN2MEN1HTTRAB9A | |
| SCHEMBL29580443 | 0.80 | HTT (0.72) | KMT2ASMN1; SMN2MEN1HTTPKM | |
| SCHEMBL9717979 | 0.80 | HTT (0.72) | KMT2ASMN1; SMN2MEN1HTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178570-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20060293342-A1 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293342-A1 | Tie-2 modulators and methods of use | TIE1, TEK, KDR | KMT2A 682/4885SMN1; SMN2 3129/4885MEN1 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.