Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 2/20 | 0.54 |
| ▸ | NOS2 | P35228 | 2/20 | 0.54 |
| ▸ | GABRP | O00591 | 4/20 | 0.47 |
| ▸ | GABRD | O14764 | 4/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.47 |
| ▸ | GABRE | P78334 | 4/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2729044 | 0.74 | NOS3 (0.65) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL7115699 | 0.73 | CPB2 (0.47) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL27542513 | 0.73 | GABRP (0.54) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4005845 | 0.72 | CPB2 (0.55) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL27542509 | 0.72 | GABRP (0.46) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL8322579 | 0.71 | NOS3 (1.00) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL7046428 | 0.70 | NOS3 (0.68) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL27517454 | 0.69 | CPB2 (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL554353 | 0.68 | NOS3 (0.70) | NOS3NOS1NOS2GABRPGABRD | |
| SCHEMBL7049168 | 0.68 | NOS3 (0.59) | NOS3NOS1NOS2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1263739-C | Carboxypeptidase U inhibiting compounds, process for their preparation, pharmaceutical compositions containing them and their use | ASTRAZENECA AB (SE) | 2006-07-12 | — | — | CN | claimed |
| CN-1263739-C | Carboxypeptidase U inhibiting compounds, process for their preparation, pharmaceutical compositions containing them and their use | ASTRAZENECA AB (SE) | 2006-07-12 | — | — | CN | disclosed |
| CN-1358174-A | New Compounds | ASTRAZENECA AB (SE) | 2002-07-10 | — | — | CN | disclosed |