Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466000 | 0.81 | ACHE (0.39) | SLC18A3TYMPKMT2A | |
| SCHEMBL2378473 | 0.78 | CA12 (0.45) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL6646583 | 0.78 | CA12 (0.48) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL27881190 | 0.78 | CA12 (0.52) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL2372804 | 0.78 | CA12 (0.52) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL3377039 | 0.76 | CA12 (0.47) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL14937974 | 0.76 | CA12 (0.47) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL7403025 | 0.74 | LSS (0.45) | KMT2A | |
| SCHEMBL1231703 | 0.74 | CA12 (0.39) | CA12CA1CA2CA9 | |
| SCHEMBL1862926 | 0.74 | CA12 (0.39) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1267431-C | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2006-08-02 | — | — | CN | disclosed |