Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9279873 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL6470401 | 0.76 | HTR2A (0.57) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL27666861 | 0.76 | HTR2A (0.70) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL29941662 | 0.76 | HTR2A (0.70) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL5692300 | 0.76 | HTR2A (0.70) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL707958 | 0.76 | HTR2A (0.70) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL31611562 | 0.74 | CYP2D6 (0.54) | SMN1; SMN2HTR2ASLC6A2HTR2CSLC6A4 | |
| SCHEMBL9350178 | 0.74 | CYP2D6 (0.54) | SMN1; SMN2HTR2ASLC6A2HTR2CSLC6A4 | |
| SCHEMBL7149267 | 0.74 | SMN1; SMN2 (0.62) | SMN1; SMN2HTR2AADRB1HTR1AADRA2A | |
| SCHEMBL28555239 | 0.74 | GPR84 (0.53) | HTR2ASLC6A2HTR2CSLC6A4HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100339379-C | 2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-1,3-dihydoimidazo{1,2-a}pyrimidin-5(1h)one derivatives | SANOFI AVENTIS (FR) | 2007-09-26 | — | — | CN | disclosed |
| CN-1267432-C | 2-pyridyl-6, 7,8, 9-tetrahydropyrimido [1, 2-a ] pyrimidin-4-one and 7-pyridyl-2, 3-dihydroimidazo [1, 2-a ] pyrimidin-5 (1H) one derivatives | SANOFI SYNTHELABO (FR) | 2006-08-02 | — | — | CN | disclosed |
| CN-1247584-C | 1- [ alkyl ], 1- [ (heteroaryl) alkyl ] and 1- [ (aryl) alkyl ] -7-pyridyl-imidazo [1, 2-a ] pyrimidin-5 (1H) -one derivatives | SANOFI AVENTIS (FR) | 2006-03-29 | — | — | CN | disclosed |