Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | HRH1 | P35367 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764220 | 0.83 | MAPT (0.41) | MAPTMAOBMAOACYP3A4ALDH1A1 | |
| SCHEMBL694287 | 0.83 | MAOB (0.48) | MAOB | |
| SCHEMBL28593515 | 0.72 | MEN1 (0.40) | MAOBCYP3A4CYP2D6CHRM1HRH1 | |
| SCHEMBL17397341 | 0.72 | TAAR1 (0.37) | MAOBTDP1 | |
| SCHEMBL1681280 | 0.70 | MAOA (0.63) | MAPTMAOBMAOACYP3A4TDP1 | |
| SCHEMBL6426912 | 0.68 | HRH3 (0.48) | MAPTTBXA2RCYP3A4HTR6GFER | |
| SCHEMBL28097821 | 0.68 | HRH3 (0.48) | MAPTTBXA2RCYP3A4HTR6GFER | |
| SCHEMBL9015445 | 0.68 | GBA1 (0.41) | MAPTTBXA2RCYP3A4HTR6GFER | |
| SCHEMBL28600129 | 0.68 | LMNA (0.40) | MAOBMAOACYP3A4CYP2D6CHRM1 | |
| SCHEMBL2916291 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1303374-A | Substituted indolinones, process for their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2001-07-11 | — | — | CN | disclosed |