Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28745016 | 0.88 | SRD5A2 (0.36) | SRD5A2MAPTLMNAHTTHPGD | |
| SCHEMBL14198824 | 0.84 | ALDH1A1 (0.61) | SRD5A2MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL27335562 | 0.82 | PLA2G10 (0.53) | MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL27556690 | 0.82 | KMT2A (0.61) | MAPTLMNAHTTHPGDALDH1A1 | |
| SCHEMBL27335185 | 0.82 | ALDH1A1 (0.41) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL28997882 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL28332051 | 0.80 | CA2 (0.59) | ALDH1A1 | |
| SCHEMBL20493785 | 0.79 | MPO (0.55) | MAPTLMNAHTTALDH1A1PLK1 | |
| SCHEMBL22542648 | 0.79 | KMT2A (0.42) | MAPTLMNAALDH1A1KMT2APLK1 | |
| SCHEMBL27968649 | 0.79 | GSK3B (0.55) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104093709-B | It is used as the imidazole derivative of aldosterone synthase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-09-22 | — | — | CN | claimed |
| CN-104093709-A | Imidazolylketone derivatives as aldosterone synthase inhibitors | HOFFMANN LA ROCHE | 2014-10-08 | — | — | CN | claimed |
| CN-101675053-B | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2014-03-12 | — | — | CN | claimed |
| CN-101675053-A | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2010-03-17 | — | — | CN | claimed |
| CN-109232366-A | The preparation method and applications of 2- acyl group -3- amino indole class compound | 华中师范大学 | 2019-01-18 | — | — | CN | disclosed |
| CN-104093709-B | It is used as the imidazole derivative of aldosterone synthase inhibitors | 霍夫曼-拉罗奇有限公司 | 2017-09-22 | — | — | CN | disclosed |
| CN-104093709-A | Imidazolylketone derivatives as aldosterone synthase inhibitors | HOFFMANN LA ROCHE | 2014-10-08 | — | — | CN | disclosed |
| CN-101675053-B | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2014-03-12 | — | — | CN | disclosed |
| CN-101675053-A | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH INC | 2010-03-17 | — | — | CN | disclosed |
| CN-100508978-C | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors | MERCK & CO INC MERCK FROSST CA (US) | 2009-07-08 | — | — | CN | disclosed |
| CN-1856461-A | Cycloalkylene compounds as estrogen receptor modulators | SMITHKLINE BEECHAM CORP (US) | 2006-11-01 | — | — | CN | disclosed |
| CN-1551769-A | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors | — | 2004-12-01 | — | — | CN | disclosed |
| CN-1305486-A | Novel compounds derived from alpha-D-xylose, preparation method and therapeutic use | FOURNIER IND & SANTE (FR) | 2001-07-25 | — | — | CN | disclosed |