Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 10/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903190 | 0.81 | KMT2A (0.48) | MAPTMEN1KMT2APIN1ALDH1A1 | |
| SCHEMBL18779299 | 0.77 | PIN1 (0.47) | MEN1KMT2APIN1ALDH1A1 | |
| SCHEMBL17110470 | 0.77 | PIN1 (0.47) | MEN1KMT2APIN1ALDH1A1 | |
| SCHEMBL2071618 | 0.74 | MAPT (0.45) | MAPTMEN1KMT2APIN1ALDH1A1 | |
| SCHEMBL14127720 | 0.73 | ADORA1 (0.61) | ADORA1ADORA2AKMT2ALMNA | |
| SCHEMBL1414668 | 0.73 | DHFR (0.53) | MAPTDHFRCLK1PIN1ALDH1A1 | |
| SCHEMBL6358902 | 0.72 | DHFR (0.51) | MAPTDHFRCLK1PIN1ALDH1A1 | |
| SCHEMBL4582424 | 0.72 | ADORA1 (0.83) | ADORA1ADORA2AMAPTKMT2ANPSR1 | |
| SCHEMBL29419380 | 0.72 | L3MBTL1 (0.49) | MAPTDHFRCLK1PIN1ALDH1A1 | |
| SCHEMBL3305092 | 0.72 | PIN1 (0.71) | MAPTMEN1KMT2APIN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100506801-C | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2009-07-01 | — | — | CN | disclosed |
| CN-1592743-A | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2005-03-09 | — | — | CN | disclosed |
| CN-1312807-A | Inhibitors of glycogen synthase kinase 3 | CHIRON CORP (US) | 2001-09-12 | — | — | CN | disclosed |