Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11376130 | 0.85 | GAA (0.50) | GAACA1CA2CA12CA9 | |
| SCHEMBL3165483 | 0.84 | MMP2 (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL5685531 | 0.82 | ALDH1A1 (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL3482784 | 0.82 | MMP2 (0.47) | GAACA1CA2CA12CA9 | |
| SCHEMBL28982333 | 0.82 | GAA (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL28982277 | 0.82 | TSHR (0.46) | GAACA1CA2CA12CA9 | |
| SCHEMBL28582803 | 0.82 | MEN1 (0.42) | CA1CA2CA12CA9ALDH1A1 | |
| SCHEMBL10914263 | 0.82 | CA9 (0.48) | GAACA1CA2CA12CA9 | |
| SCHEMBL28513057 | 0.81 | HTR6 (0.42) | CA1CA2CA12CA9CA3 | |
| SCHEMBL8955512 | 0.80 | GAA (0.45) | GAACA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102939291-A | Phosphonates with reduced toxicity for treatment of viral infections | UNIV CALIFORNIA | 2013-02-20 | — | — | CN | disclosed |
| CN-100402539-C | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same | GILEAD SCIENCES INC (US) | 2008-07-16 | — | — | CN | disclosed |
| CN-1291994-C | Nucleotide phosphonate analogue prodrug and screening and preparing method thereof | GILEAD SCIENCES INC (US) | 2006-12-27 | — | — | CN | disclosed |
| CN-1706855-A | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same | GILEAD SCIENCES INC (US) | 2005-12-14 | — | — | CN | disclosed |
| CN-1443189-A | Nucleotide phosphonate analogue prodrug and screening and preparing method thereof | GILEAD SCIENCES INC (US) | 2003-09-17 | — | — | CN | disclosed |