Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10411824 | 0.90 | ALDH1A1 (0.67) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL8412585 | 0.88 | ALDH1A1 (0.78) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL10499238 | 0.87 | LMNA (0.63) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL10360804 | 0.87 | ALDH1A1 (0.77) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL4243105 | 0.86 | ALDH1A1 (0.57) | ALDH1A1LMNAHSD17B10TSHRHIF1A | |
| SCHEMBL8877393 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL2439695 | 0.86 | ALDH1A1 (0.76) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL29056995 | 0.86 | ALDH1A1 (0.66) | ALDH1A1LMNAHSD17B10POLBTSHR | |
| SCHEMBL10438855 | 0.85 | CYP4F2 (0.58) | ALDH1A1LMNAHSD17B10TSHRKMT2A | |
| SCHEMBL9030516 | 0.85 | ALDH1A1 (0.73) | ALDH1A1LMNAHSD17B10POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854141-B | Catalyst components for the polymerization of olefins | 巴塞尔聚烯烃意大利有限公司 | 2020-03-10 | — | — | CN | disclosed |
| US-10336717-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, LLC (US) | 2019-07-02 | — | — | US | disclosed |
| US-10336717-B2 | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS, LLC (US) | 2019-07-02 | — | — | US | disclosed |
| EP-2859026-B1 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF BUTENE-1 | BASELL POLIOLEFINE ITALIA SRL (IT) | 2017-06-28 | — | — | EP | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, LLC | 2016-09-22 | — | — | US | disclosed |
| EP-2859024-B1 | CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS | BASELL POLIOLEFINE SRL (IT) | 2016-04-27 | — | — | EP | disclosed |
| EP-2406240-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2406240-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2015-12-23 | — | — | EP | disclosed |
| WO-2010105179-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010105179-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010057865-A1 | N- INDEN- 2 -YL- ISOPROPYLSULFONAMIDES AS AMPA RECEPTOR POTENTIATORS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057865-A1 | N- INDEN- 2 -YL- ISOPROPYLSULFONAMIDES AS AMPA RECEPTOR POTENTIATORS | GLAXO GROUP LIMITED (GB) | 2010-05-27 | — | — | WO | disclosed |
| EP-0542554-B1 | Substituted N-biphenylyl lactams | ORTHO PHARMA CORP (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5246940-A | Angoitensin II receptor antagonist for hypertension, stroke or diabetes | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0542554-A1 | Substituted N-biphenylyl lactams | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5182288-A | Angiotensin II receptor antagonists | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0002624-B1 | 2-BENZAZEPINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1981-10-14 | — | — | EP | disclosed |
| EP-0002624-A1 | 2-Benzazepine compounds, processes for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10336717-B2 | Inhibitors of beta-secretase | BACE1, BACE2, PSEN1 | ALDH1A1 2962/4885LMNA 521/4885HSD17B10 834/4885 |
| US-20160272600-A1 | INHIBITORS OF BETA-SECRETASE | BACE1, BACE2, PSEN1 | ALDH1A1 2962/4885LMNA 521/4885HSD17B10 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.