Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27552 | 0.86 | ALDH1A1 (0.76) | ALDH1A1LMNATDP1TSHRHIF1A | |
| SCHEMBL9844983 | 0.85 | ALDH1A1 (0.53) | ALDH1A1LMNATDP1TSHRCYP2C9 | |
| SCHEMBL10438855 | 0.85 | CYP4F2 (0.58) | ALDH1A1LMNATDP1TSHRCYP4F2 | |
| SCHEMBL8695949 | 0.85 | HTT (0.56) | ALDH1A1LMNATDP1TSHRKDM4E | |
| Phthalic Acid SCHEMBL28233805 | 0.83 | ALDH1A1 (0.58) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL23884678 | 0.83 | CYP4F2 (0.67) | ALDH1A1LMNAFOLH1TDP1TSHR | |
| SCHEMBL7380269 | 0.83 | ALDH1A1 (0.64) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL3916488 | 0.82 | FOLH1 (0.50) | ALDH1A1LMNAFOLH1TSHRCYP2C9 | |
| SCHEMBL6802490 | 0.82 | FOLH1 (0.51) | ALDH1A1LMNAFOLH1TSHRCYP2C9 | |
| SCHEMBL30339213 | 0.82 | FOLH1 (0.51) | ALDH1A1LMNAFOLH1TSHRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12234202-B2 | Covalent inhibitors of coronavirus papain-like protease | UT-BATTELLE, LLC (US) | 2025-02-25 | — | — | US | disclosed |
| US-20240317707-A1 | COVALENT AND NON-COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE | U. S. DEPARTMENT OF ENERGY | 2024-09-26 | — | — | US | disclosed |
| US-20240245673-A1 | Papain-like protease (PLpro) inhibitors | PFIZER INC. (US) | 2024-07-25 | — | — | US | disclosed |
| WO-2024121779-A1 | PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS | PFIZER INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| WO-2024121709-A1 | PAPAIN-LIKE PROTEASE (PLPRO) INHIBITORS | PFIZER INC. (US) | 2024-06-13 | — | — | WO | disclosed |
| WO-2023223055-A1 | ANTI-VIRAL COMPOUNDS | Infex Therapeutics Limited (GB) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023064493-A1 | COMPOUNDS AND METHODS FOR TREATING CORONAVIRUSES | Clear Creek Bio, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |
| US-20230102656-A1 | COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE | U. S. DEPARTMENT OF ENERGY | 2023-03-30 | — | — | US | disclosed |
| WO-2023028286-A1 | COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE | UT-BATTELLE, LLC (US) | 2023-03-02 | — | — | WO | disclosed |
| US-9328057-B2 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE' FARMACEUTICI S.P.A. (IT) | 2016-05-03 | — | — | US | disclosed |
| WO-2002051810-A2 | INTEGRIN RECEPTOR LIGANDS | ABBOTT GMBH & CO. KG (DE) | 2002-07-04 | — | — | WO | disclosed |
| US-20020019416-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-14 | — | — | US | disclosed |
| CN-1056602-C | Esters and amides as PLA2 inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-09-20 | — | — | CN | disclosed |
| CN-1197450-A | Esters and amides as phospholipase A2 inhibitors | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-10-28 | — | — | CN | disclosed |
| EP-0854863-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997003951-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-06 | — | — | WO | disclosed |
| US-4885313-A | 3,4-Dihydroxyphenylethylamine derivatives and their use | FISONS PLC (GB) | 1989-12-05 | — | — | US | disclosed |
| US-4803225-A | Dihydroxy-phenethylamino compounds useful as pharmaceuticals | FISONS, PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| US-4720586-A | Substituted 3,4-dihydroxy-phenylethylamino compounds | FISONS, PLC (GB) | 1988-01-19 | — | — | US | disclosed |
| EP-0142283-A2 | Phenylethylamines, process for their preparation and compositions containing them | FISONS plc (GB) | 1985-05-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12234202-B2 | Covalent inhibitors of coronavirus papain-like protease | CPN1, CTRL, CTRC | ALDH1A1 1621/4885LMNA 2147/4885FOLH1 1205/4885 |
| US-20230102656-A1 | COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE | CPN1, CTRL, CTRC | ALDH1A1 1621/4885LMNA 2147/4885FOLH1 1205/4885 |
| US-20240245673-A1 | Papain-like protease (PLpro) inhibitors | PREP, PEPD, ACE | ALDH1A1 2220/4885LMNA 1294/4885FOLH1 634/4885 |
| US-20020019416-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | PLA2G4A, PLA2G4B, PLA2G1B | ALDH1A1 700/4885LMNA 3290/4885FOLH1 3878/4885 |
| US-20240317707-A1 | COVALENT AND NON-COVALENT INHIBITORS OF CORONAVIRUS PAPAIN-LIKE PROTEASE | HPN, CTRL, CPN1 | ALDH1A1 2872/4885LMNA 4032/4885FOLH1 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.