Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10716701 | 0.87 | LOXL2 (0.42) | HTTGAAMAPTCYP19A1LOXL2 | |
| SCHEMBL5604550 | 0.79 | CTBP2 (0.48) | HTTGAAMAPTALDH1A1KDM4E | |
| SCHEMBL5604545 | 0.79 | CTBP2 (0.48) | HTTGAAMAPTALDH1A1KDM4E | |
| SCHEMBL27399090 | 0.78 | CTBP2 (0.48) | MAPTALDH1A1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL3663329 | 0.75 | HTT (0.47) | HTTGAAMAPTCYP19A1LOXL2 | |
| SCHEMBL8507706 | 0.73 | SLC6A4 (0.41) | HTTALDH1A1CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL13268901 | 0.73 | SMN1; SMN2 (0.59) | HTTALDH1A1CYP3A4CYP2C19KDM4E | |
| SCHEMBL13268903 | 0.73 | SMN1; SMN2 (0.59) | HTTALDH1A1CYP3A4CYP2C19KDM4E | |
| SCHEMBL11134123 | 0.72 | HTT (0.41) | HTTGAAMAPTCYP19A1LOXL2 | |
| SCHEMBL6429888 | 0.71 | LOXL2 (0.44) | HTTGAAMAPTCYP19A1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1324012-C | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-07-04 | — | — | CN | disclosed |
| CN-1307159-C | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-03-28 | — | — | CN | disclosed |
| CN-1284771-C | TNF-alpha production inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2006-11-15 | — | — | CN | disclosed |
| CN-1590374-A | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-03-09 | — | — | CN | disclosed |
| CN-1590375-A | TNF-alpha prodn. inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2005-03-09 | — | — | CN | disclosed |
| CN-1432000-A | TNF-alpha production inhibitors | SANTEN PHARMACEUTICAL CO LTD (JP) | 2003-07-23 | — | — | CN | disclosed |