Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | VDR | P11473 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272933 | 0.85 | POLB (0.66) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL29450270 | 0.85 | POLB (0.70) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL9694998 | 0.85 | POLB (0.70) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL21940616 | 0.83 | POLB (0.62) | POLBALDH1A1CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL29693599 | 0.80 | POLB (0.58) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL8136134 | 0.77 | ALDH1A1 (0.55) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL23145043 | 0.76 | POLB (0.63) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL7048658 | 0.76 | CYP1A2 (0.58) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL9762619 | 0.76 | POLB (0.53) | POLBALDH1A1CYP1A2ADORA3CYP2C19 | |
| SCHEMBL22377 | 0.76 | PDE10A (0.57) | POLBALDH1A1SMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1176922-C | 8-quinolinxanthine and 8-isoquinolinxanthine derivs. as PDE 5 inhibitors | ��˹��ŵ�� | 2004-11-24 | — | — | CN | disclosed |
| CN-1420887-A | 8-quinolinxanthine and 8-isoquinolinxanthine derivs. as PDE 5 inhibitors | NOVARTIS AG (CH) | 2003-05-28 | — | — | CN | disclosed |