SCHEMBL7048658

SCHEMBL7048658

COc1nc2ccccc2c2ccccc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.58
ALDH1A1 P00352 2/20 0.58
CYP2C19 P33261 2/20 0.58
POLB P06746 4/20 0.57
MAPT P10636 2/20 0.54
ADORA3 P0DMS8 1/20 0.54
GPR3 P46089 1/20 0.54
NR1I3 Q14994 2/20 0.50
CYP3A4 P08684 1/20 0.50
VDR P11473 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2B6 P20813 1/20 0.50
AHR P35869 1/20 0.50
MAPK1 P28482 1/20 0.49
HPGD P15428 2/20 0.46
LMNA P02545 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
KDM4E B2RXH2 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13975112 0.82 PKM (0.48) CYP1A2CYP2C19POLBMAPTADORA3
SCHEMBL13975766 0.82 PKM (0.48) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL8350089 0.81 ALDH1A1 (0.52) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL13975115 0.81 ALDH1A1 (0.53) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL10102405 0.80 PRNP (0.54) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL13976026 0.80 HTR4 (0.50) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL9694998 0.79 POLB (0.70) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL6042690 0.79 LMNA (0.68) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL29450270 0.79 POLB (0.70) CYP1A2ALDH1A1CYP2C19POLBMAPT
SCHEMBL317214 0.79 MAPT (0.56) CYP1A2ALDH1A1CYP2C19POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017133517-A1 PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF 四川海思科制药有限公司 2017-08-10 WO disclosed
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed