Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL239322 | 0.99 | HTR1A (0.44) | HTR1ASLC6A2SLC6A4HTR2CCARM1 | |
| SCHEMBL2755244 | 0.78 | HPGDS (0.40) | HTR1ASLC6A2SLC6A4CARM1SLC6A3 | |
| Hydrochloric Acid SCHEMBL239078 | 0.77 | HPGDS (0.40) | HTR1ASLC6A2SLC6A4HTR2CCARM1 | |
| SCHEMBL238932 | 0.76 | PLAT (0.43) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2755230 | 0.73 | BRD4 (0.41) | HTR2CCARM1MAPK13RAF1MAPK9 | |
| SCHEMBL2755243 | 0.73 | MAP3K12 (0.42) | HTR1ASLC6A2SLC6A4HTR2CCARM1 | |
| SCHEMBL2755236 | 0.72 | GABRA1 (0.47) | GABRA1 | |
| SCHEMBL2755247 | 0.72 | CCR1 (0.42) | HTR2CMAPK14 | |
| SCHEMBL3941345 | 0.72 | HPGDS (0.50) | HTR2CGABRA1GABRB2 | |
| Hydrochloric Acid SCHEMBL236905 | 0.72 | BRD4 (0.40) | HTR2CCARM1MAPK13RAF1MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME LLC | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004240-A1 | INHIBITORS OF AKT ACTIVITY | PIK3CD, PIK3CA, PIK3R5 | HTR1A 4294/4885SLC6A2 3138/4885SLC6A4 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.