Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27552395 | 0.78 | KCNA3 (0.33) | — | |
| SCHEMBL27552406 | 0.74 | SMN1; SMN2 (0.34) | — | |
| SCHEMBL27532991 | 0.74 | MEN1 (0.31) | — | |
| SCHEMBL27528307 | 0.74 | P2RX7 (0.35) | — | |
| SCHEMBL27571469 | 0.73 | MEN1 (0.33) | — | |
| SCHEMBL28294127 | 0.71 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL27552393 | 0.68 | ENPP2 (0.33) | — | |
| SCHEMBL27552371 | 0.65 | MTNR1A (0.34) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25972265 | 0.59 | TSHR (0.46) | — | |
| SCHEMBL26502318 | 0.59 | PTGDR2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100418968-C | Pirazino(aza)indole derivatives | VERNALIS RES LTD (GB) | 2008-09-17 | — | — | CN | disclosed |
| CN-1289499-C | Pyrazino (aza) indole derivatives | VERNALIS RES LTD (GB) | 2006-12-13 | — | — | CN | disclosed |
| CN-1837207-A | Pirazino(aza)indole derivatives | VERNALIS RES LTD (GB) | 2006-09-27 | — | — | CN | disclosed |
| CN-1337963-A | Pyrazino (aza) indole derivatives | VERNALIS RES LTD (GB) | 2002-02-27 | — | — | CN | disclosed |