Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28039584 | 0.86 | ALDH1A1 (0.44) | ALDH1A1TDP1HTTALOX15NPC1 | |
| Quinoline SCHEMBL28060746 | 0.84 | ALDH1A1 (0.65) | ALDH1A1HTTALOX15NPC1POLB | |
| Quinoline SCHEMBL1697844 | 0.84 | ALDH1A1 (0.65) | ALDH1A1HTTALOX15NPC1POLB | |
| Quinoline SCHEMBL27789588 | 0.81 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15NPC1POLB | |
| Quinoline SCHEMBL28096623 | 0.79 | ALDH1A1 (0.77) | ALDH1A1TDP1HTTALOX15NPC1 | |
| Naphthalene SCHEMBL27817254 | 0.79 | TDP1 (0.65) | ALDH1A1TDP1RAB9AMEN1KMT2A | |
| Quinoline SCHEMBL28105560 | 0.79 | ALDH1A1 (0.85) | ALDH1A1TDP1HTTALOX15NPC1 | |
| Quinoline SCHEMBL5569889 | 0.79 | ALDH1A1 (0.85) | ALDH1A1TDP1HTTALOX15NPC1 | |
| Quinoline SCHEMBL27422586 | 0.79 | ALDH1A1 (0.85) | ALDH1A1TDP1HTTALOX15NPC1 | |
| Quinoline SCHEMBL29354528 | 0.77 | ALDH1A1 (0.74) | ALDH1A1HTTALOX15NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745291-A | N- (2- (4-cyanothiazolidin-3-yl) -2-oxoethyl) -quinoline-4-carboxamide | 阿斯利康(瑞典)有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-106470994-B | For treating the substituted pyrazine of CNS disease simultaneously [2,1-A] isoquinilone derivatives | 豪夫迈·罗氏有限公司 | 2019-09-24 | — | — | CN | disclosed |
| CN-109715612-A | SOMATOSTATIN MODULATORS AND USES THEREOF | 克林提克斯医药股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-106255692-B | Imidazo [4,5-c ] quinolin-2-one compounds and their use in treating cancer | 阿斯利康(瑞典)有限公司 | 2019-02-26 | — | — | CN | disclosed |
| CN-109071525-A | dimeric compounds | 豪夫迈·罗氏有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-104736519-B | Indoline-like | 霍夫曼-拉罗奇有限公司 | 2018-12-04 | — | — | CN | disclosed |
| CN-106470994-A | For treating substituted pyrazine simultaneously [2,1 A] isoquinilone derivatives of CNS disease | 豪夫迈·罗氏有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-106255692-A | Imidazo [4,5-c ] quinolin-2-one compounds and their use in treating cancer | 阿斯利康(瑞典)有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-103906735-A | Novel aryl-quinoline derivatives | HOFFMANN LA ROCHE | 2014-07-02 | — | — | CN | disclosed |
| CN-102333531-B | Treatment of dyskinesia related disorders | LUNDBECK & CO AS H | 2013-11-06 | — | — | CN | disclosed |
| CN-101616902-B | 2-aminooxazolines as TAAR1 ligands | HOFFMANN LA ROCHE CH | 2013-03-27 | — | — | CN | disclosed |
| CN-102333531-A | Treatment of dyskinesia related disorders | LUNDBECK & CO AS H | 2012-01-25 | — | — | CN | disclosed |
| CN-102333524-A | Methods of administering (4ar, 1oar)-i-n-propyl-i, 2,3,4a7 s1io7 ioa-octahydrobenzo [g] quinoline-6,7-diol and related compounds across the oral mucosa, the nasal mucosa or the skin and pharmaceutical compositions thereof | LUNDBECK & CO AS H | 2012-01-25 | — | — | CN | disclosed |
| CN-102282133-A | decahydro-1H-indenoquinolinone and decahydro-3H-cyclopentaphenanthrenone CYP17 inhibitors | — | 2011-12-14 | — | — | CN | disclosed |
| CN-102017525-A | Inhibitors of checkpoint kinases | MERCK & CO INC | 2011-04-13 | — | — | CN | disclosed |
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | disclosed |
| CN-101316821-A | Dihydro-[1h]-quinolin-2-one derivatives as rxr agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-03 | — | — | CN | disclosed |
| CN-1331858-C | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as CRTP inhibitors | PFIZER PROD INC (US) | 2007-08-15 | — | — | CN | disclosed |
| CN-1318058-A | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines as CRTP inhibitors | PFIZER PROD INC (US) | 2001-10-17 | — | — | CN | disclosed |