Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | AGER | Q15109 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | STK4 | Q13043 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412662 | 0.83 | BCL6 (0.52) | KMT2AKDM4EMAPTTSHRL3MBTL1 | |
| SCHEMBL20920576 | 0.79 | KDM4E (0.63) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL5631503 | 0.77 | MAPT (0.49) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL27760101 | 0.77 | MEN1 (0.50) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL4110255 | 0.77 | PIK3CA (0.52) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL27781485 | 0.77 | MEN1 (0.48) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL20406682 | 0.75 | STK4 (0.47) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL16604040 | 0.74 | KDM4E (0.67) | LMNAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL10414485 | 0.72 | CYP11B2 (0.58) | MEN1KMT2AKDM4ETSHRHSD17B10 | |
| SCHEMBL6586305 | 0.72 | DHPS (0.55) | LMNAMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100424079-C | Bis-sulfonamides | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-08 | — | — | CN | disclosed |
| CN-1335839-A | Bis-sulfonamides | ACTELION PHARMACEUTICALS LTD (CH) | 2002-02-13 | — | — | CN | disclosed |