Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10192581 | 0.69 | SIGMAR1 (0.40) | KMT2ASIGMAR1ALDH1A1LSS | |
| SCHEMBL27538469 | 0.69 | ROCK2 (0.40) | KMT2APROKR1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL27590384 | 0.69 | ROCK2 (0.40) | KMT2APROKR1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL19986729 | 0.67 | SIGMAR1 (0.45) | SIGMAR1LSS | |
| SCHEMBL22573037 | 0.67 | KAT2B (0.50) | — | |
| SCHEMBL24721280 | 0.66 | SIGMAR1 (0.42) | SIGMAR1SMN1; SMN2LSS | |
| SCHEMBL690716 | 0.66 | SIGMAR1 (0.42) | SIGMAR1SMN1; SMN2LSS | |
| SCHEMBL13935740 | 0.66 | SIGMAR1 (0.42) | SIGMAR1SMN1; SMN2LSS | |
| SCHEMBL27557137 | 0.66 | COMT (0.36) | KMT2AALOX5APALDH1A1SMN1; SMN2 | |
| SCHEMBL23323163 | 0.66 | CHRNB2 (0.44) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1297555-C | antagonists of MCP-1 function and methods of use thereof | TELIK INC (US) | 2007-01-31 | — | — | CN | disclosed |